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An explosion in the heart of Baghdad kills at least 25 people and leaves nearly 50 others wounded. The blast, which investigators say was the result of a 1,000-pound car bomb, left a huge crater outside the Mount Lebanon hotel, which was nearly destroyed by the blast. Hear NPR's Robert Siegel and NPR's Steve Inskeep.

Though Democrats don't have the votes to pass such a bill, the Senate majority leader insisted voting on it wouldn't be "an abstract exercise," putting every senator's stance on the record.

Four Southern states hold primaries this week, and Sen. John Kerry is making an all-out effort to have impressive victories in the South on his way to the nomination. The Democratic candidate made several jabs at President George Bush at a campaign rally in San Antonio, Texas. NPR's David Welna reports.

Biden says the reasoning in the leaked Supreme Court draft would mean "every other decision related to the notion of privacy is thrown into question," including contraception and gay marriage.

A new study finds that aggressively lowering cholesterol levels far below current recommendations can substantially reduce the risk of heart attacks and other heart disease. Experts say the results of the study, which looked at high-intensity treatment with drugs known as statins, are likely to alter heart disease treatment. Hear NPR's Renee Montagne and NPR's Richard Knox.

Republicans launch a drive to register 3 million new voters, promoting the effort from the cab of a semi called Reggie the Registration Rig. Meanwhile, the Committee to Redefeat the President -- a group headed by a Democratic activist -- launches its own registration drive this week. Hear NPR's Pam Fessler.

Two years after Congress changed the laws governing campaign financing, both supporters and opponents of the new measures say they've found vindication. Special-interest money, however, is seeking new ways to influence politics in 2004. NPR's Peter Overby reports.

In his new book, Disarming Iraq, Blix writes about what happened in the months leading up to the war in Iraq last year. Blix, formerly the head of the U.N. Monitoring, Verification and Inspection Commission, has been named chairman of the newly formed International Commission on Weapons of Mass Destruction, which began its work in January 2004.

Senior news analyst NPR's Daniel Schorr says many voters chose to support Sen. John Kerry in Tuesday's primaries for reasons having more to do with his "winnability" than his stance on the issues -- but that those reasons may change in the months leading up to the election.

Commentator Matt Miller says President Bush is deceiving Americans when he says government spending is out of control. Miller says it's a way to keep the government from doing -- and paying for -- what's needed.