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The Orphan Drug Act was created to help patients with rare diseases get life-saving medications. But soaring prices suggest the law is being manipulated to increase profits.

Centrist independent Emmanuel Macron and far-right leader Marine Le Pen lead the first round of the French presidential election. Both are poised to compete in a May runoff.

Years of treating grievously injured people starts to wear on a person, a trauma nurse in Minneapolis says. She explores "compassion fatigue" in a semi-autobiographical poem.

The new AG held his first on-record briefing as head of the Justice Department on Monday. He said he's "not a fan" of legalized marijuana use, and threats against Jewish centers are unacceptable.

A U.S. general says Russia has violated a longstanding arms control treaty by deploying new missiles. It was the first official, public assertion that these missiles are fully operational.

During Rooney's time steering the team his father founded, the Pittsburgh Steelers reached the heights of the NFL. Off the field he also spearheaded efforts to diversify the league's hiring practices.

Becca Longo, 18, says she wasn't aware she might be making history when she accepted a scholarship from Adams State University in Colorado.

Jason Chaffetz, the Utah Republican, says he will not seek any office in 2018 — tamping down speculation that he could challenge Sen. Orrin Hatch in a re-election bid.

At the Air Force museum in Dayton, technicians and volunteers are working to restore a unique piece of history. The B-17 bomber Memphis Belle is being carefully returned to its wartime appearance.

A day before the International Toy Fair opened in New York, Toys R Us announced it was laying off between 10 and 15 percent of its corporate employees.