How The White House Got 2 Pharma Rivals To Work Together On COVID-19 Vaccine

Mar 3, 2021
Originally published on March 3, 2021 5:41 am

President Biden said on Tuesday that a key milestone in the fight against COVID-19 could be reached two months faster than earlier projected. By the end of May, there should be enough vaccine doses for every adult in America, he said — a dramatic improvement to his initial timetable for late July.

A turning point in speeding up that pledge came a few weeks ago, on a Sunday afternoon in early February, during a phone call with Johnson & Johnson executives that had been planned for 15 minutes but stretched for longer than an hour, two senior administration officials told NPR.

Biden administration officials had been pushing vaccine-makers to find ways to get more doses faster. Early talks with Moderna and Pfizer led to increased commitments. "Those are some of the hardest negotiations — I've done a lot of them," said one of the officials involved in the talks.

Then there was Johnson & Johnson. Its single-dose vaccine looked promising, but even before it had been approved for emergency use, it was clear that the company would not be able to meet its contracted production.

Then came the call, where White House officials got on the line with J&J executives to talk about the urgency of the situation.

"The basic conclusion of that call was, we've got to think much bigger and much bolder," recalled a senior administration official who was on the line. "We have to take bold action and overwhelm this."

That February call helped lead to an agreement with Merck — a competitor that had given up on its own vaccine work — to help produce J&J's vaccine and use its facilities to get it into vials.

The two companies had held some preliminary talks about working together before the Biden team got into the White House, but those proposals had been "at a very small level of ambition" and were "dead by the time we got in" to office, said the official, who knew the CEOs of both companies.

The official called J&J CEO Alex Gorsky to express concern and later called Merck CEO Kenneth Frazier. "I said, 'You know — heads up — there might be a need for Merck to help here,'" the official recalled.

But it was after the early February phone call that officials felt like J&J had embraced the push, said a second official who was involved in the talks. "They understood this was a wartime effort. This was their legacy. This was their time."

The Defense Production Act, which gives the government the power to compel companies to support war effort, provided some "implicit" incentive for the companies to cooperate, administration officials said. "You have the potential to use the DPA if there isn't cooperation," one of the officials said.

The resulting agreement came with an invocation of the DPA that helped accelerate some J&J vaccine deliveries to May that had earlier been set for June. It also will provide assistance to Merck. President Biden announced J&J would be running its U.S. facilities "24/7" to speed vaccine out the door.

Merck said it would receive up to $268.8 million in government funding to make adjustments to its facilities, where it will fill vials with J&J's vaccine and eventually also produce the drug substance used in the J&J vaccine. In a brief statement, Johnson & Johnson said it was "pleased to collaborate" with Merck on the arrangement to boost production.

The officials said getting Merck involved will vastly increase production of the Johnson & Johnson vaccine in the "medium term." That capacity may be needed to produce doses to vaccinate children, an official said, or to make a booster if variants diminish the efficacy of the current vaccine.

The Biden administration is racing against variants of COVID-19 that could make the existing vaccines less effective. Beyond simply getting the vaccines made and put into vials, they also have to get doses into arms, which is a massive undertaking involving everything from standing up mass vaccination clinics to recruiting retired medical professionals to administer shots. Soon the emphasis will turn from scarcity to persuasion as the administration and public health officials work to reach people who may be reluctant to get the vaccine.

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News in the last day seems to bring the possible waning of the pandemic in the United States a little bit nearer. President Biden says that by the end of May, vaccines should be available for every American adult who wants one. That is sooner than expected. Not that everybody will be vaccinated, but supplies should be on hand at least. So what changed? Let's begin our coverage with NPR White House correspondent Tamara Keith. Good morning.


INSKEEP: How did the date move up from July to May?

KEITH: Last night, I spoke with two senior officials who were deeply involved in the negotiations that are making this happen. First thing they did was renegotiate the contracts for the two vaccines that were already approved when they came into office. That's the Moderna and Pfizer vaccines. So they increased the number of doses and moved up the timeline for when they would be delivered. One of the officials told me that these were the hardest talks he's ever been involved in and that none of it was simple.

And then there were more tough talks with Johnson & Johnson. They had - they got emergency use authorization from the FDA over the weekend for their vaccine. But J&J has been running behind schedule and wasn't going to meet its contractual obligations. So the White House stepped in with significant interventions to speed up production.

INSKEEP: Well, let's talk about what that intervention was. The White House says, Johnson & Johnson, you're going to bring in Merck, your rival, to help produce your vaccine. How'd that come about?

KEITH: It wasn't exactly dictated quite like that, but this is a really unusual partnership. There had been preliminary talks between the two companies that broke down before Biden came into office. Merck had been trying to develop its own vaccine but gave up on that on January 25.

And a little backstory - the administration officials knew the CEOs of both companies, and there were a lot of phone calls and check-ins and constant urging to go bigger. But they credit this call on a Sunday in February as a turning point. It was between administration officials and Johnson & Johnson. It was only supposed to last 15 minutes, but it went more than an hour. And the officials said that in the end, J&J knew that this was their time, their legacy. They had to think bigger, be bolder.

Here's how President Biden put it yesterday.


PRESIDENT JOE BIDEN: As I've always said, this is a wartime effort. And every action has been on the table, including putting together breakthrough approaches.

KEITH: There was a bit of help from the Defense Production Act to accelerate the contract. And the federal government is giving Merck up to $269 million to work with J&J on getting its vaccines out. But this is all more medium term. The immediate stuff is the renegotiation of those contracts to speed up deliveries.

INSKEEP: OK, so this all sounds very good, but we've got to be very clear - this is prospective. It's in the future. It's officials saying what they think will happen. What could go wrong?

KEITH: There could certainly be production problems. And as you mentioned before, there's going to need to be a massive ramp-up to get these shots into people's arms. Still, this is really good news, and it's something to be a bit hopeful about a year into this really terrible pandemic.

INSKEEP: Tam, thanks so much.

KEITH: You're welcome.

INSKEEP: NPR White House correspondent Tamara Keith. Transcript provided by NPR, Copyright NPR.