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The two cities are the latest to tighten public health rules to combat the spread of the omicron variant. Chicago is seeing its highest number of hospitalizations and rate of deaths in months.

In small studies in South Africa and in Germany, the results indicate a marked decrease in the ability of vaccines to neutralize this variant. But there are other findings that are encouraging.

"This wave seems much faster than the delta wave. And we thought the delta wave was really fast. It's unbelievable," says Juliet Pulliam, the scientist who presented the new analysis at a conference.

Hospitalizations in New York City, the original heart of the pandemic in early 2020, are growing exponentially because of omicron, and have now surpassed last winter's peak.

The omicron wave in the U.S. will likely continue to the end of January, then start to recede rapidly. Former advisers to President Biden say a new strategy is needed to help the U.S. live with COVID.

Employers from Macy's to United Airlines are having to adjust after skyrocketing omicron COVID cases have led large numbers of workers to call out sick.

The Biden administration massively expanded hospital-level care at home as part of its strategy to enhance hospital capacity. The Mayo Clinic says it's having an impact.

NPR's Rachel Martin talks to Yonty Friesem of Columbia College Chicago about a new law in Illinois that requires high school students to receive lessons on media literacy.

September's existing home sales dropped 24% from a year ago — to the lowest level in a decade. Prices fell too. Higher mortgage rates have thrown cold water on the once hot market.

Sarah M. Broom's extraordinary memoir about the New Orleans home she grew up in describes decades of life lived — as well as the systemic racism that ultimately contributed to the house's destruction.